TMS for Complex Regional Pain Syndrome

Trial ID or NCT#



recruiting iconRECRUITING


The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.

Official Title

Transcranial Magnetic Stimulation (TMS) for Complex Regional Pain Syndrome (CRPS)

Eligibility Criteria

Ages Eligible for Study: 18 Years to 70 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Age 18-70 - Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months - Average pain level reported on Numerical Rating Scale meets entry criteria - Ability to perform the experimental task and procedures.
Exclusion Criteria:
  1. - MRI contraindication (metal implants or devices, claustrophobia) - TMS Contraindication (eg metal implant or devices near the site of stimulation) - History of epilepsy - History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher. - Neurologic illness that would interfere with brain integrity - Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher. - Currently pregnant or planning to become pregnant. - On going legal action or disability claim.


Sean Mackey, M.D., Ph.D.
Sean Mackey, M.D., Ph.D.
Pain management specialist, Pain management specialist, Anesthesiologist
Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology

Contact us to find out if this trial is right for you.


Kristen H Scherrer