THRIVE Feasibility Trial

Trial ID or NCT#

NCT05346588

Status

not recruiting iconNOT RECRUITING

Purpose

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

Official Title

Feasibility Study for the Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia (THRIVE) Trial

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - 18 years or older - Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia, including a tracheal tube or laryngeal mask airway (or similar supra-glottic device)
Exclusion Criteria:
  1. - Inability to provide informed consent in English - Pregnancy (based on patient report or positive test on the day of surgery) - Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date - Contraindication to propofol TIVA or inhaled volatile (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) - Surgical procedures requiring specific general anesthesia option (for example, TIVA required for neuromonitoring). - Hospital approved, written protocol mandating a particular technique - History of intraoperative awareness during general anesthesia based on patient self-report on the day of consent - Planned postoperative intubation
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Investigator(s)

Lawrence Chu, MD, MS
Lawrence Chu, MD, MS
Anesthesiologist
Professor of Anesthesiology, Perioperative and Pain Medicine

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Contact

Larry Chu, MD, MS

View on ClinicalTrials.gov