Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
Trial ID or NCT#
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training. In addition, this project aims to identify physiological factors that may bolster effects of the training on cognitive function. Individuals with MCI are at high risk for Alzheimer's disease (AD). Understanding how cognitive training protects cognitive function in MCI can contribute to development of effective interventions to slow progression to AD in individuals at risk, thereby reducing the significant morbidity and health care costs associated with AD.
Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults With Mild Cognitive Impairment
- - a clinical diagnosis of "mild cognitive impairment due to Alzheimer's disease" using the most recent NIA and Alzheimer's Association workshop criteria within 3 months: a) must have memory deficit (1-1.5SD below age- and education-corrected population norms); b) may have deficits in other cognitive domains (e.g., executive function); c) preserved BADL, defined as requiring occasional assistance on less than two items on the Minimum Data Set-Home Care interview, d) absence of dementia using NINCDS-ADRDA criteria; - if on AD medication (i.e., memantine or cholinesterase inhibitors), no changes of doses in the 3 months prior to recruitment; - capacity to give consent based on clinician assessment; and - other: age ≥60 years, English-speaking, adequate visual acuity for testing, and community-dwelling.
- - current enrollment in another cognitive improvement study; - major depression: 15-item Geriatric Depression Scale scored > 7; - MRI contraindications, e.g., metallic implant, pacemaker, claustrophobia; and - major vascular diseases: stroke, myocardial infarction, congestive heart failure.