XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors
Trial ID or NCT#
The purpose of this study is to compare the safety and efficacy of XERECEPT® to dexamethasone (Decadron) a common treatment for symptoms of brain swelling (edema). This study is specifically aimed at patients who require chronic high doses of dexamethasone to manage symptoms.
A Phase III Randomized, Double-Blind, Dexamethasone-Sparing Study Comparing Human Corticotropin-Releasing Factor (hCRF) to Placebo for Control of Symptoms Associated With Peritumoral Brain Edema in Patients With Malignant Brain Tumor Who Require Chronic Administration of High-Dose Dexamethasone
- - Histologically confirmed diagnosis of a primary malignant brain tumor or, if metastatic, documentation and histology (if available) of primary source of cancer. - Patient must have 1 or more qualifying steroid-associated side effect(s) at Baseline. - Patient has required administration of dexamethasone to control symptoms of peritumoral edema for at least 30 days. - Stable dexamethasone dose of 4-24 mg/day for at least 14 days prior to Baseline. - Need for administration of dexamethasone to treat peritumoral brain edema (referenced above) has been documented by MRI or comparable diagnostic technology within 21 days of Baseline. - Karnofsky score of > 50 at Screening and Baseline. - Capable of self-administration of subcutaneous injections twice daily for 12 weeks, or availability of assistance from caregiver. - Ability to provide written informed consent or, if unable to provide, have a legal guardian or representative provide written informed consent. - For women of childbearing potential: a negative serum pregnancy test at Screening. - Must be 18 years of age or older
- - Ongoing or anticipated need for surgery, radiosurgery or radiation therapy or the introduction of new chemotherapeutic regime within the first 5 weeks of study enrollment. Treatment with pre-study chemotherapy may continue. - Concurrent enrollment in any other investigational drug or device study, or plan to enroll in such a study during the first 5 weeks of treatment. - Systemic steroid use for any indication other than peritumoral brain edema. - Use or intended use of dexamethasone as an anti-emetic during Screening or Study - Non-compliance with dexamethasone or anticonvulsant therapy. - Clinical signs and symptoms of cerebral herniation. - Serious concomitant cardiovascular, pulmonary, renal, gastrointestinal or endocrine metabolic disease which could put the patient at unusual risk for study participation. - Confounding previous or concurrent neurological disorders that would interfere with adequate clinical evaluation. - Clinically significant head injury or chronic seizure disorder, if the condition results in functional impairment or is likely to interfere with evaluations. (Maintenance anticonvulsant therapy is allowed.) - Central nervous system infection. - Pregnancy, breastfeeding and/or refusal to practice birth control while in study, for women of childbearing potential. - Any conditions that are considered contraindications for patients to receive niacin, e.g. liver disease (with LFTs > 3 times the upper limit of the norm),active peptic ulcer, arterial hemorrhage, asthma and known hypersensitivity to niacin.
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