Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C VIRUSES-BASEL Margeridon-Thermet, S., Shafer, R. W. 2010; 2 (12): 2696-2739


Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are the most prevalent deadly chronic viral diseases. HIV is treated by small molecule inhibitors. HBV is treated by immunomodulation and small molecule inhibitors. HCV is currently treated primarily by immunomodulation but many small molecules are in clinical development. Although HIV is a retrovirus, HBV is a double-stranded DNA virus, and HCV is a single-stranded RNA virus, antiviral drug resistance complicates the development of drugs and the successful treatment of each of these viruses. Although their replication cycles, therapeutic targets, and evolutionary mechanisms are different, the fundamental approaches to identifying and characterizing HIV, HBV, and HCV drug resistance are similar. This review describes the evolution of HIV, HBV, and HCV within individuals and populations and the genetic mechanisms associated with drug resistance to each of the antiviral drug classes used for their treatment.

View details for DOI 10.3390/v2122696

View details for Web of Science ID 000285725600008

View details for PubMedID 21243082

View details for PubMedCentralID PMC3020796