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The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone PEPTIDES Kathpalia, P. P., Charlton, C., Rajagopal, M., Pao, A. C. 2011; 32 (5): 1068-1072

Abstract

Gamma-Melanocyte Stimulating Hormone (Gamma-MSH) regulates sodium (Na(+)) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R). The mechanism of the natriuretic effect is proposed to involve binding of MC3-R either in the kidney to directly inhibit tubular Na(+) transport or in the brain to inhibit central neural pathways that control renal tubular Na(+) absorption. This study aimed to clarify the mechanism involved in the natriuretic effect of Gamma-MSH on MC3-R in kidney cells. In Ussing chamber studies, we observed no effects of Gamma-MSH on NaCl transport in the mouse inner medullary collecting duct cell line (mIMCD-K2). We also found that neither MC3-R protein nor mRNA was expressed in mouse kidney, suggesting that renal Gamma-MSH action may not be mediated through direct effects on tubular Na(+) transport but rather through effects on central neural pathways that innervate the kidney.

View details for DOI 10.1016/j.peptides.2011.02.006

View details for Web of Science ID 000291286200032

View details for PubMedID 21335042

View details for PubMedCentralID PMC3112371