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The role of lipid droplets in metabolic disease in rodents and humans JOURNAL OF CLINICAL INVESTIGATION Greenberg, A. S., Coleman, R. A., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., Yan, Q., Miyoshi, H., Mashek, D. G. 2011; 121 (6): 2102-2110

Abstract

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.

View details for DOI 10.1172/JCI46069

View details for Web of Science ID 000291234300007

View details for PubMedID 21633178

View details for PubMedCentralID PMC3104768