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Expression of Apoptotic Factors in Vaginal Tissues From Women With Urogenital Prolapse NEUROUROLOGY AND URODYNAMICS Wen, Y., Ho, J. Y., Polan, M. L., Chen, B. 2011; 30 (8): 1627-1632

Abstract

Increased apoptotic activity in pelvic tissues may contribute to development of pelvic floor disorders. We evaluated expression of apoptotic factors (Bcl-2 family) in vaginal tissues from women with pelvic organ prolapse (POP) and how these factors correlate with severity of prolapse.mRNA and protein expression of anti-apoptotic and pro-apoptotic factors in vaginal tissues from subjects and controls were determined by real-time PCR and Western blot. Severity of prolapse was staged using POP-Q criteria.Differential expression of Bcl-2 family factors was observed in protein rather than in gene expression. During the secretory phase, the anti-apoptotic (Bcl-2, Bcl-xl) and pro-apoptotic protein (Bax) were upregulated in controls compared to cases (P?

View details for DOI 10.1002/nau.21127

View details for Web of Science ID 000296425200046

View details for PubMedID 21674599