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Emerging Treatments and Signaling Pathway Inhibitors

Emerging Treatments and Signaling Pathway Inhibitors SEMINARS IN CUTANEOUS MEDICINE AND SURGERY Tang, J. Y., Marghoob, A. A. 2011; 30 (4): S14-S18

Abstract

A number of therapies that target components of the Hedgehog signaling pathway currently are in clinical trials. The specific molecules that seem most promising in basal cell carcinoma and a number of other cancers are those that target the Smoothened transmembrane protein. The pivotal phase II trials have been completed on the Smoothened inhibitor known as GDC-0449; five other agents (BMS-833923, LDE225, LEQ506, IPI926, and TAK-441) have also shown promise in animal studies and early clinical trials and have shown some efficacy in a variety of cancers that are affected by the Hedgehog signaling pathway.

View details for DOI 10.1016/j.sder.2011.11.002

View details for Web of Science ID 000298710300004

View details for PubMedID 22177102