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INFLUENCE OF AGE ON THE PHARMACOKINETICS OF ALFENTANIL - GENDER DEPENDENCE CLINICAL PHARMACOKINETICS Lemmens, H. J., Burm, A. G., Hennis, P. J., GLADINES, M. P., Bovill, J. G. 1990; 19 (5): 416-422

Abstract

Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = -0.79, p less than 0.001) between plasma alfentanil clearance (CL) and age in women (less than 50y, median CL 24.84 L/h; greater than 50y, median CL 14.52 L/h), but not in men (less than 50y, median CL 19.44 L/h; greater than 50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent.

View details for Web of Science ID A1990EK28000005

View details for PubMedID 2268988