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Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES Blish, C. A., McClelland, R. S., Richardson, B. A., Jaoko, W., Mandaliya, K., Baeten, J. M., Overbaugh, J. 2012; 61 (4): 436-440

Abstract

In women, genital HIV-1 RNA levels predict the risk of HIV-1 transmission independent of plasma viral load. To better understand the factors that contribute to genital HIV-1 shedding, we evaluated the relationships between genital and plasma cytokine concentrations and HIV-1 RNA levels. Vaginal, but not plasma, levels of interferon gamma-induced protein 10 (IP-10) were significantly associated with vaginal viral load, independent of plasma viral load. Thus, efforts to decrease HIV-1 transmission must take into account the role of local inflammation, which is not necessarily reflected in plasma measurements.

View details for DOI 10.1097/QAI.0b013e31826c2edd

View details for Web of Science ID 000311083200008

View details for PubMedID 22878424

View details for PubMedCentralID PMC3494808