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The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells ADVANCED MATERIALS Lee, W., Park, J. 2012; 24 (39): 5339-5344

Abstract

The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method of building a hierarchical cellular structure by stacking cell-attached microplate structures with specific configurations within hydrogel layers. This method is applied to the reconstruction of the 3D architecture of a liver lobule and the development of an experimental model of the various phases of cancer angiogenesis.

View details for DOI 10.1002/adma.201200687

View details for Web of Science ID 000309405200006

View details for PubMedID 22927197