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Individualized Dosing With Anesthetic Agents CLINICAL PHARMACOLOGY & THERAPEUTICS Lemmens, H. J., Stanski, D. R. 2012; 92 (4): 417-419

Abstract

The development of fundamental pharmacokinetics and pharmacodynamics concepts has enabled anesthesiologists to choose and dose anesthetic agents on a rational basis. The application of these concepts to a variety of clinical scenarios and patient populations makes it possible to individualize the dose, thereby decreasing the risk of complications. As more knowledge is gained about the sometimes profound differences in drug response, empirical dosing such as in milligrams per kilogram of total body weight is disappearing from the anesthesia specialty.

View details for DOI 10.1038/clpt.2012.131

View details for Web of Science ID 000309017000010

View details for PubMedID 22992669