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IgG4-positive Sclerosing Orbital Inflammation Involving the Conjunctiva: A Case Report OCULAR IMMUNOLOGY AND INFLAMMATION Paulus, Y. M., Cockerham, K. P., Cockerham, G. C., Gratzinger, D. 2012; 20 (5): 375-377

Abstract

To describe IgG4-positive sclerosing orbital inflammation with prominent conjunctival and scleral involvement.Case report.Clinical, radiologic, and pathologic correlation.A 66-year-old man presented with right eye redness and irritation. Examination revealed unilateral scleritis and nongranulomatous anterior uveitis with elevated p-ANCA and CRP. Orbital CT scan showed inferotemporal scleral thickening. Biopsy revealed sclerosis and IgG4-positive plasma cells in the conjunctiva and inferior rectus.IgG4-mediated sclerosing inflammation is well-recognized in the orbit and adnexa, particularly the lacrimal gland. Scleritis with anterior uveitis should be recognized as a possible presentation for this entity, which has important systemic associations.

View details for DOI 10.3109/09273948.2012.709574

View details for Web of Science ID 000309471900011

View details for PubMedID 23030356