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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade NUCLEIC ACIDS RESEARCH Liu, Y. Z., Boxer, L. M., Latchman, D. S. 1999; 27 (10): 2086-2090

Abstract

The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.

View details for Web of Science ID 000080431800004

View details for PubMedID 10219080

View details for PubMedCentralID PMC148427