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Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection. Journal of acquired immune deficiency syndromes Forthal, D. N., Landucci, G., Chohan, B., Richardson, B. A., McClelland, R. S., Jaoko, W., Blish, C., Overbaugh, J. 2013; 63 (1): 31-33

Abstract

Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.

View details for DOI 10.1097/QAI.0b013e3182874d41

View details for PubMedID 23344546

View details for PubMedCentralID PMC3625514