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Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation CELLULAR AND MOLECULAR LIFE SCIENCES Butte, M. J. 2001; 58 (8): 1003-1013

Abstract

The neutrophin family, the glial-derived neurotrophic factor family, and the ciliary neurotrophic factor are the best described growth factors specific for developing neurons and neutral crest cells. As might be expected for regulatory molecules of the complex central and peripheral nervous system, these factors show considerable receptor specificity and cross-talk. Thanks to a decade of intense research by numerous laboratories, the structures of many of these factors are now available. This review discusses the structural bases of receptor binding, specificity, and activation in each of these systems. Using structure-based sequence alignments, the evolutionary implications of these molecules and their receptors are discussed, followed by suggestions for further directions for research on the structure and function of these neurotrophic factors.

View details for Web of Science ID 000170535200002

View details for PubMedID 11529493