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PRETREATMENT WITH THE NMDA ANTAGONIST DEXTROPHAN REDUCES CEREBRAL INJURY FOLLOWING TRANSIENT FOCAL ISCHEMIA IN RABBITS
PRETREATMENT WITH THE NMDA ANTAGONIST DEXTROPHAN REDUCES CEREBRAL INJURY FOLLOWING TRANSIENT FOCAL ISCHEMIA IN RABBITS BRAIN RESEARCH Steinberg, G. K., Saleh, J., Delapaz, R., Kunis, D., Zarnegar, S. R. 1989; 497 (2): 382-386Abstract
We studied the efficacy of systemic pre-treatment with dextrorphan (DX), a clinically tested N-methyl-D-aspartate (NMDA) antagonist, in a rabbit model of transient focal cerebral ischemia. Rabbits were treated with either a 24 mg/kg i.v. loading dose followed by 12 mg/kg/h i.v. infusion of 0.48% DX in normal saline (NS), or with an equivalent volume of NS alone. One and 1/2 h after starting the drug or NS, the rabbits underwent a 1 h occlusion of the left internal carotid and anterior cerebral arteries, followed by 4 h of reperfusion. The DX-treated rabbits had significantly less neocortical ischemic neuronal damage (7.4%) than the normal saline group (31.6%) and demonstrated a significant decrease in ischemic cortical edema. DX may prove useful in the treatment of clinical cerebrovascular disease.
View details for Web of Science ID A1989AR53400022
View details for PubMedID 2684345