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T cell antigen receptor vaccines for active therapy of T cell malignancies

T cell antigen receptor vaccines for active therapy of T cell malignancies Conference on Basic and Clinical Relevant Biology of Cutaneous T Cell Lymphoma Reddy, S. A., Okada, C., Wong, C., Bahler, D., Levy, R. NEW YORK ACAD SCIENCES. 2001: 97–105

Abstract

T cell lymphoproliferative disorders continue to be serious management problems, and so alternative therapeutic modalities are continuously being explored. One such strategy involves immunotherapy using the T cell receptor (TCR) as a target. Specifically we are attempting to develop a T cell receptor idiotype (TCR-Id) vaccine because the TCR-Id can serve as a tumor-specific antigen. In this article we will briefly review the rationale for TCR-Id vaccines, the preclinical models as developed in our laboratory, and a discussion of our current plans for a vaccine trial in mycosis fungoides.

View details for Web of Science ID 000172619000010

View details for PubMedID 11594586