Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

HUMAN MONOCLONAL-ANTIBODIES NEUTRALIZING VARICELLA-ZOSTER VIRUS JOURNAL OF INFECTIOUS DISEASES Foung, S. K., Perkins, S., KOROPCHAK, C., Fishwild, D. M., Wittek, A. E., Engleman, E. G., GRUMET, F. C., Arvin, A. M. 1985; 152 (2): 280-285

Abstract

Hybridomas secreting human monoclonal antibodies to varicella-zoster virus were produced by fusing B cells of a patient recovering from acute varicella infection with a human-mouse cell line. Two hybrid lines have continued to secrete IgG1, one with kappa and the other with lambda chains, for at least 12 months. Each antibody neutralizes virus infectivity between 1-5 micrograms of partially purified immunoglobulin/ml, each shows a different pattern of immunofluorescent staining of virus-infected cells, and one identifies three viral proteins with molecular weights of 60,000, 95,000, and 97,000.

View details for Web of Science ID A1985AQZ7900006

View details for PubMedID 2993433