New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
IMMUNOTHERAPY OF ESTABLISHED MURINE B-CELL LYMPHOMA - COMBINATION OF IDIOTYPE IMMUNIZATION AND CYCLOPHOSPHAMIDE
IMMUNOTHERAPY OF ESTABLISHED MURINE B-CELL LYMPHOMA - COMBINATION OF IDIOTYPE IMMUNIZATION AND CYCLOPHOSPHAMIDE JOURNAL OF IMMUNOLOGY Campbell, M. J., Esserman, L., Levy, R. 1988; 141 (9): 3227-3233Abstract
A murine B cell lymphoma (38C13) was used to study the efficacy of idiotype immunotherapy against established tumors. Immunization of mice with 38C13 tumor-derived Ig, administered after a lethal tumor inoculation, significantly prolonged survival of animals compared to control groups. The efficacy of active immunotherapy was dramatically enhanced when combined with chemotherapy. Cyclophosphamide (100 mg/kg), administered in combination with idiotype immunization to mice bearing 10-day-old, 1 to 2 cm diameter s.c. tumors, resulted in a significant prolongation of survival as compared with either cyclophosphamide or immunization alone and yielded approximately 50% cures. Additional studies combining active immunotherapy with surgical excision of the primary s.c. tumor nodule were less effective than combination chemoimmunotherapy, indicating that reduction of tumor burden was necessary, but not sufficient for effective treatment of established 38C13 lymphoma.
View details for Web of Science ID A1988Q532300054
View details for PubMedID 3049819