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AGE HAS NO EFFECT ON THE PHARMACODYNAMICS OF ALFENTANIL ANESTHESIA AND ANALGESIA Lemmens, H. J., Bovill, J. G., Hennis, P. J., Burm, A. G. 1988; 67 (10): 956-960

Abstract

Effects of age on the pharmacodynamics of alfentanil, as a supplement to nitrous oxide anesthesia, were studied in younger (31-52 years; n = 14) and older (56-86 years; n = 14) women undergoing curative surgery for primary breast cancer. Plasma alfentanil concentration-effect curves for perioperative stimuli and for the probability of needing naloxone at the end of the operation were fitted by logistic regression. Effects of age on the plasma concentration-effect relation of alfentanil could not be demonstrated. However, the dose requirement in the older patient group was significantly lower than in the younger patient group.

View details for Web of Science ID A1988Q324000008

View details for PubMedID 3138925