XANTHOMA OF THE TEMPORAL BONE AND SKULL BASE AMERICAN JOURNAL OF OTOLOGY Jackler, R. K., Brackmann, D. E. 1987; 8 (2): 111-115

Abstract

Xanthomata are soft tissue tumors composed of lipid-laden "foamy" histiocytes associated with cholesterol clefts and inflammation. They are considered to be specialized granuloma rather than true neoplasms and are usually associated with disorders of lipid metabolism, most commonly one of the hyperlipoproteinemia syndrome. A rare case of a xanthoma involving the temporal bone and causing extensive destruction of the skull base is presented. Otalgia and infection are the most common presenting symptoms of this disorder, with multiple cranial nerve palsies resulting in some cases. Treatment includes conservative surgical debulking, dietary restriction of fat and cholesterol, and pharmacologic reduction of serum lipids.

View details for Web of Science ID A1987H111200007

View details for PubMedID 3591917