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ROLE FOR HEME IN MAMMALIAN PROTEIN-SYNTHESIS - ACTIVATION OF AN INITIATION-FACTOR PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Raffel, C., Stein, S., Kaempfer, R. 1974; 71 (10): 4020-4024

Abstract

Two nonerythropoietic tissues, brian and liver, contain an initiation factor that can overcome the block in initiation of protein synthesis seen in reticulocyte lysates when exogenous hemin is not present. Upon incubation of the brain factor with hemin and removal of free hemin by gel filtration, the factor activity is strongly stimulated. This stimulation shows a concentration dependence on hemin close to that seen for stimulation of protein synthesis in whole reticulocyte lysates. The data indicate that hemin mediates the formation of an active initiation factor complex from inactive, lower molecular weight components.

View details for Web of Science ID A1974U614000051

View details for PubMedID 4530282