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BIOSYNTHETIC METHIONYL HUMAN GROWTH-HORMONE IS BIOLOGICALLY-ACTIVE IN ADULT MAN LANCET Hintz, R. L., Wilson, D. M., FINNO, J., Rosenfeld, R. G., Bennett, A., MCCLELLAN, B. 1982; 1 (8284): 1276-1279

Abstract

The acute effects of synthetic methionyl human growth hormone produced by recombinant DNA technology were compared with those of pituitary human growth hormone in 22 healthy male volunteers. Both caused increases in somatomedin and triglycerides and decreases in blood urea nitrogen and cholesterol. By all indices measured, synthetic methionyl human growth hormone was equipotent with pituitary human growth hormone. The ability to make biologically active synthetic human growth hormone creates an essentially unlimited supply of growth hormone for the treatment of hypopituitarism and for the study of additional therapeutic indications.

View details for Web of Science ID A1982NT14800005