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THE THYMIC DIFFERENTIATION MARKER-T6 AND MARKER-M241 ARE 2 UNUSUAL MHC CLASS-I ANTIGENS JOURNAL OF IMMUNOLOGY VANDERIJN, M., Lerch, P. G., Knowles, R. W., TERHORST, C. 1983; 131 (2): 851-855

Abstract

The human beta 2-microglobulin (beta-2m)-associated human thymocyte differentiation antigens T6 and M241 were compared using biochemical techniques. T6 and M241 antigens reside on different molecules with apparent m.w. of 49,000 and 43,000, respectively. Here we show that both proteins have a protein backbone m.w. of 33,000. In addition, T6 and M241 have a large portion of their peptides in common. When we compared the protein backbone m.w. of T6 and M241 with the murine beta-2m-associated thymus leukemia (TL) antigens, we found a considerable difference in size, suggesting that T6 and M241 may not be human homologues of TL antigens and constitute a novel type of major histocompatibility (MHC) class I antigens.

View details for Web of Science ID A1983QZ47000058

View details for PubMedID 6190941