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MISONIDAZOLE NEUROTOXICITY IN RATS .2. EFFECT OF PRETREATMENT AND INTERMITTENT TREATMENT WITH PENTOBARBITAL ON MISONIDAZOLE NEUROTOXICITY IN THE RAT JOURNAL OF NEURO-ONCOLOGY Edwards, M. S., Gordon, D. G., SALAMY, A., Levin, V. A., Phillips, T. L. 1984; 2 (2): 95-98

Abstract

Rats pretreated for 5 days with 50 mg/kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently.

View details for Web of Science ID A1984SW26800002

View details for PubMedID 6481429