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PHASE-II EVALUATION OF DIBROMODULCITOL IN THE TREATMENT OF RECURRENT MEDULLOBLASTOMA, EPENDYMOMA, AND MALIGNANT ASTROCYTOMA JOURNAL OF NEUROSURGERY Levin, V. A., Edwards, M. S., Gutin, P. H., VESTNYS, P., Fulton, D., Seager, M., Wilson, C. B. 1984; 61 (6): 1063-1068

Abstract

The authors have conducted a Phase II trial to evaluate orally administered dibromodulcitol in the treatment of 40 evaluable patients with recurrent medulloblastoma, ependymoma, and malignant astrocytoma. Ten of 20 patients harboring medulloblastoma responded to therapy with a median time to tumor progression (MTP) of 40 weeks, and four of 20 patients had no sign of progression of disease 4 years after treatment was begun. The MTP for all 12 patients with ependymoma was 30 weeks. Nine of these 12 patients had stabilization of their disease with an MTP of 67 weeks; three of these 12 patients had no signs of progression for 1 to 3 years after treatment was begun. Of six patients harboring supratentorial gliomas, none responded to dibromodulcitol. Two patients, one with a primitive neuroectodermal tumor and the other with a metastatic carcinoma of the breast, had stabilization of disease for more than 4 and 2 years, respectively.

View details for Web of Science ID A1984TT89800009

View details for PubMedID 6502234