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INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS SCIENCE Kazmers, I. S., Mitchell, B. S., DADONNA, P. E., Wotring, L. L., Townsend, L. B., Kelley, W. N. 1981; 214 (4525): 1137-1139

Abstract

The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.

View details for Web of Science ID A1981MR19800027

View details for PubMedID 6795718