Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS
INHIBITION OF PURINE NUCLEOSIDE PHOSPHORYLASE BY 8-AMINOGUANOSINE - SELECTIVE TOXICITY FOR T-LYMPHOBLASTS SCIENCE Kazmers, I. S., Mitchell, B. S., DADONNA, P. E., Wotring, L. L., Townsend, L. B., Kelley, W. N. 1981; 214 (4525): 1137-1139Abstract
The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.
View details for Web of Science ID A1981MR19800027
View details for PubMedID 6795718