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ADENOSINE PRODUCES PULMONARY VASODILATION IN THE PERFUSED RABBIT LUNG VIA AN ADENOSINE A(2) RECEPTOR
ADENOSINE PRODUCES PULMONARY VASODILATION IN THE PERFUSED RABBIT LUNG VIA AN ADENOSINE A(2) RECEPTOR ANESTHESIA AND ANALGESIA Pearl, R. G. 1994; 79 (1): 46-51Abstract
Adenosine is a potent pulmonary vasodilator that has been used in therapy for clinical and experimental pulmonary hypertension. To determine the receptor responsible for adenosine-induced pulmonary vasodilation, we studied the relative potency of four adenosine agonists in the isolated buffer-perfused rabbit lung during pulmonary hypertension due to infusion of the thromboxane A2 mimetic U46619. The ED50 values for pulmonary vasodilation were 1.9 x 10(-8) mol/L for 5'-N-ethylcarboxamidoadenosine (NECA), 4.5 x 10(-8) mol/L for 2-phenylaminoadenosine (CV-1808), 2.6 x 10(-6) mol/L for R(-)-N6-(2-phenylisopropyl) adenosine (R-PIA), and 6.5 x 10(-6) mol/L for cyclopentyladenosine, results consistent with an adenosine A2 receptor. Pretreatment with the adenosine A1 receptor antagonist cyclopentyltheophylline did not affect the dose-response curve to NECA, and pretreatment with the adenosine A2 receptor antagonist CGS 15943A increased the ED50 of NECA to 2.7 x 10(-7) mol/L. These results suggest that adenosine produces pulmonary vasodilation via activation of an adenosine A2 receptor.
View details for Web of Science ID A1994NU61200010
View details for PubMedID 8010453