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DECREASED HIPPOCAMPAL MUSCARINIC CHOLINERGIC RECEPTOR-BINDING MEASURED BY I-123 IODODEXETIMIDE AND SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN EPILEPSY ANNALS OF NEUROLOGY MULLERGARTNER, H. W., Mayberg, H. S., Fisher, R. S., Lesser, R. P., Wilson, A. A., Ravert, H. T., Dannals, R. F., WAGNER, H. N., Uematsu, S., Frost, J. J. 1993; 34 (2): 235-238

Abstract

Regional binding of 123I-iododexetimide, a muscarinic acetylcholine receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single-photon emission computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123I-iododexetimide binding was decreased by 40 +/- 9% (mean +/- SD, p < 0.01) compared with the contralateral hippocampus; 123I-iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.

View details for Web of Science ID A1993LR02400019

View details for PubMedID 8338348