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Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients JOURNAL OF INFECTIOUS DISEASES Suzuki, Y., Wong, S. Y., GRUMET, F. C., Fessel, J., Montoya, J. G., Zolopa, A. R., PORTMORE, A., SCHUMACHERPERDREAU, F., Schrappe, M., Koppen, S., Ruf, B., Brown, B. W., Remington, J. S. 1996; 173 (1): 265-268

Abstract

The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

View details for Web of Science ID A1996TM34300042

View details for PubMedID 8537674