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Dynamics of virus versus host interaction in children with human immunodeficiency virus type 1 infection JOURNAL OF INFECTIOUS DISEASES Sei, S., Akiyoshi, H., Bernard, J., VENZON, D. J., Fox, C. H., Schwartzentruber, D. J., Anderson, B. D., Kopp, J. B., Mueller, B. U., Pizzo, P. A. 1996; 173 (6): 1485-1490

Abstract

To investigate the dynamic interplay between human immunodeficiency virus type I (HIV-1) replication and the extent of immune destruction in HIV-1-infected children, virus burden in lymphoid tissues (LN) and peripheral blood was compared with changes in LN architecture and cytokine levels constitutively expressed in LN. In agreement with results of a preliminary study, the plasma HIV-1 RNA level correlated with the amount of provirus in LN. However, the level was also associated with a degree of destruction of lymphoid follicular architecture and an alteration of immune cytokine expression. Expression of interleukin (IL)-4 was higher in LN with higher virus replication. Reduction of plasma viremia was associated with an increase in IL-2 mRNA levels in LN. These findings suggest that measurable virus burden in the peripheral blood is not a simple reflection of viral replication in LN but is also influenced by the extent of progressive immune destruction.

View details for Web of Science ID A1996UM11500027

View details for PubMedID 8648226