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Seroprevalence of CagA-positive strains among Helicobacter pylori-infected, healthy young adults

Seroprevalence of CagA-positive strains among Helicobacter pylori-infected, healthy young adults 1996 Digestive Diseases Week Meeting Parsonnet, J., Replogle, M., Yang, S. F., Hiatt, R. OXFORD UNIV PRESS INC. 1997: 1240–42

Abstract

Helicobacter pylori is categorized into two phenotypes on the basis of the presence or absence of the CagA protein. CagA protein-positive H. pylori are more closely associated with peptic ulcer disease and cancer. Whether CagA-positive strains are similarly represented among racial or ethnic groups in northern California was investigated. Sera from 152 H. pylori-infected healthy young adults were tested by ELISA for IgG against CagA. CagA antibodies were detected in 79.4% of blacks, 63.8% of Hispanics, and 50% of whites. After adjusting for demographic factors, blacks had significantly more infections with CagA-positive H. pylori than did whites (odds ratio [OR] = 5.0; 95% confidence interval [CI] = 1.6-15.3) or Hispanics (OR = 5.5, 95% CI = 1.9-16.0). Also, there was a higher prevalence of CagA in persons born in developing countries than in persons born in industrialized nations (OR = 3.5, 95% CI = 1.3-9.4). This suggests either a genetic predisposition of racial or ethnic groups to infection with particular H. pylori phenotypes or transmission of H. pylori within relatively segregated population groups.

View details for Web of Science ID A1997WW72600033

View details for PubMedID 9129095