Skip to main content
 
Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
Stanford Health Care

Risk for gastric lymphoma in persons with CagA(+) and CagA(-) Helicobacter pylori infection

Risk for gastric lymphoma in persons with CagA(+) and CagA(-) Helicobacter pylori infection Digestive Diseases Week 97 Meeting Witherell, H. L., Hansen, S., Jellum, E., Orentreich, N., Vogelman, J. H., Parsonnet, J. OXFORD UNIV PRESS INC. 1997: 1641–44

Abstract

Infection with Helicobacter pylori increases the risk for gastric non-Hodgkin's lymphoma (GNHL). Strains that express CagA protein are thought to be particularly virulent. It was determined whether CagA+ H. pylori infection increased the risk for GNHL more than CagA infection. Thirty-two cases and 130 controls previously tested for H. pylori antibodies were tested for CagA antibodies by ELISA. The risk for GNHL was compared among CagA+, CagA-, and uninfected persons by use of conditional logistic regression. CagA+ subjects had 8.2 times the risk for GNHL than uninfected persons (95% confidence interval [CI], 2.5-26.7). CagA- subjects had 4.4 times the risk for GNHL than uninfected persons (95% CI, 1.2-16.5). Among infected subjects only, CagA+ infection was not associated with significantly increased risk for GNHL when compared with CagA- infection (odds ratio, 2.1; 95% CI, 0.8-5.4). This study does not support a major role for CagA in lymphomagenesis.

View details for Web of Science ID A1997YH16000035

View details for PubMedID 9395383