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Involvement of interleukin-3 in delayed-type hypersensitivity BLOOD MACH, N., Lantz, C. S., GALLI, S. J., Reznikoff, G., Mihm, M., Small, C., Granstein, R., Beissert, S., Sadelain, M., Mulligan, R. C., Dranoff, G. 1998; 91 (3): 778-783

Abstract

The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity.

View details for Web of Science ID 000071644000007

View details for PubMedID 9446636