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Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo JOURNAL OF IMMUNOLOGY Ridgway, W., Fasso, M., Fathman, C. G. 1998; 161 (2): 714-720

Abstract

The low precursor frequency of Ag-specific T cells has raised significant barriers to studying the T cell response in vivo. We demonstrate that T cells up-regulate the cell surface expression of CD4 following Ag recognition, which identifies Ag-specific T cells in vitro and in vivo and allows their characterization. The CD4high cell subpopulation contains the Ag-specific population as indicated by Ag-induced proliferation and limiting dilution analyses. The use of the CD4high marker will allow analysis of the dynamics of the T cell immune response in vivo, the study of the suboptimal T cell response to Ag, and the identification of T cells which are reactive to known and unknown autoantigens.

View details for Web of Science ID 000074728400024

View details for PubMedID 9670947