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Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein HORMONE RESEARCH Loh, K. C., Matthay, K. K., Hoover, M., Bracho, F. A., Cortez, A. B., Conte, F. A., Albanese, C. T., Miller, T. R., Price, D. C., Flores, A. J., Kaviani, A., Shoback, D. 1998; 50 (4): 217-221

Abstract

A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively.

View details for Web of Science ID 000077541100005

View details for PubMedID 9838243