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Polymeric gadolinium chelate magnetic resonance imaging contrast agents: Design, synthesis, and properties BIOCONJUGATE CHEMISTRY Ladd, D. L., Hollister, R., Peng, X., Wei, D., Wu, G., Delecki, D., Snow, R. A., Toner, J. L., Kellar, K., Eck, J., Desai, V. C., Raymond, G., Kinter, L. B., Desser, T. S., Rubin, D. L. 1999; 10 (3): 361-370

Abstract

We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.

View details for Web of Science ID 000080553100007

View details for PubMedID 10346865