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Engineered Two-Helix Small Proteins for Molecular Recognition CHEMBIOCHEM Webster, J. M., Zhang, R., Gambhir, S. S., Cheng, Z., Syud, F. A. 2009; 10 (8): 1293-1296

Abstract

Less is more: By starting with a high-affinity HER2-binding 3-helix affibody molecule, we successfully developed 2-helix small protein binders with 5 nM affinities by using a combination of several different strategies. Our efforts clearly suggest that 2-helix small proteins against important tumor targets can be obtained by rational protein design and engineering.

View details for DOI 10.1002/cbic.200900062

View details for Web of Science ID 000266561500003

View details for PubMedID 19422008