Elevations of serum phosphorus and potassium in mild to moderate chronic renal insufficiency NEPHROLOGY DIALYSIS TRANSPLANTATION Hsu, C. Y., Chertow, G. M. 2002; 17 (8): 1419-1425


Reduced renal function is associated with a variety of biochemical abnormalities. However, the extent of these changes and their magnitude in relation to renal function is not well defined, especially among individuals with mild to moderate chronic renal insufficiency (CRI).We analysed the Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994) data for 14722 adults aged >/=17 years with measurements of serum creatinine and all electrolytes including ionized calcium. General linear models were used to determine the relationship between mean concentrations of electrolytes and different levels of Cockcroft-Gault creatinine clearance (CrCl). Sample weights were used to produce weighted regression parameters.Changes in mean serum phosphorus and potassium concentration were evident at relatively modest reductions in CrCl (around 50 to 60 ml/min). Changes in the anion gap and mean levels of ionized calcium and bicarbonate were not apparent until CRI was advanced (CrCl 80 ml/min, those with CrCl 60-50, 50-40, 40-30, 30-20 and

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View details for PubMedID 12147789