Preferential involvement of larger vessels in a rat model of diabetes induced graft vasculopathy JOURNAL OF HEART AND LUNG TRANSPLANTATION Cantin, B., Zhu, D., Wen, P. Z., Panchal, S. N., Gwathmey, J. K., Reaven, G. M., Valantine, H. A. 2002; 21 (9): 1040-1043


Using previously described models of diabetes-induced transplant coronary artery atherosclerosis (TxCAD), we quantitatively assessed TxCAD using computer-assisted morphometric measurements. More than 95% of the evaluated vessels were intramyocardial vessels. The first and last tertile of the vessel size distribution were evaluated for the presence of TxCAD. Severe TxCAD, defined as a luminal occlusion > or =75%, was more prevalent in the larger vessels. We observed a differential involvement based on vessel size in diabetes-induced TxCAD.

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View details for PubMedID 12231376