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Growth slowing after acute Helicobacter pylori infection is age-dependent

Growth slowing after acute Helicobacter pylori infection is age-dependent JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION Passaro, D. J., TAYLOR, D. N., Gilman, R. H., Cabrera, L., Parsonnet, J. 2002; 35 (4): 522-526

Abstract

Most infections occur during childhood, but the health effects of childhood infection are poorly understood. We investigated whether growth decreases in the 2 months after acute seroconversion.We performed a nested case-control study among children 6 months to 12 years of age in a community on the outskirts of Lima, Peru. Health interviews were completed daily. Anthropometric measurements were taken monthly. Sera were collected every 4 months and tested for immunoglobulin G. Two-month height and weight gains of seroconverters were compared with gains of sex, age, and size-matched seronegative controls.In the 2 months after infection, 26 seroconverters gained a median of 24% less weight than 26 matched controls (interquartile range, 63% less to 21% more). In multivariate analysis, infection attenuated weight gain only among children aged 2 years or older. This decrease was not explained by increased diarrhea.seroconversion is associated with a slowing of weight gain in children aged 2 years or older. Reasons for this finding merit additional study.

View details for Web of Science ID 000178665500012

View details for PubMedID 12394378