MRI of Frozen Tissue Demonstrates a Phase Shift MAGNETIC RESONANCE IN MEDICINE Lu, A., Daniel, B. L., Kaye, E., Pauly, K. B. 2011; 66 (6): 1582-1589


While temperature mapping is desired during cryosurgery for prostate cancer treatment, an effective approach for this purpose is still needed. We have demonstrated a phase shift with temperature in our in vivo canine experiments and ex vivo tissue sample experiments within the frozen tissue. The phase shift is much larger (~0.7 °/°C with an echo time of 0.1 ms at 0.5 T) in magnitude than that predicted by conventional proton resonant frequency shift (0.008 °/°C). It shows little dependence on the echo times used and thus is not due to a frequency change, although frequency-dependent phase shift has been observed near the frozen tissue. This phase shift varies monotonically with temperature within the frozen tissue and therefore may be potentially used as a novel temperature mapping approach in cryoablation applications.

View details for DOI 10.1002/mrm.22953

View details for Web of Science ID 000297285000012

View details for PubMedID 21630347

View details for PubMedCentralID PMC3166360