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Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study FERTILITY AND STERILITY Green, D. M., Nolan, V. G., Kawashima, T., Stovall, M., Donaldson, S. S., Srivastava, D., Leisenring, W., Robison, L. L., Sklar, C. A. 2011; 95 (6): 1922-U76

Abstract

To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy.Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers.Self-administered questionnaire.A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (=0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants.None.Self-reported pregnancy events.As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97-1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses=22 Gy compared with those CCS receiving no HPT RT.These results support the hypothesis that exposures of 22-27 Gy HPT RT may be a contributing factor to infertility among female CCS.

View details for DOI 10.1016/j.fertnstert.2011.02.002

View details for Web of Science ID 000289620900016

View details for PubMedID 21376314

View details for PubMedCentralID PMC3080448