A randomized trial of exercise training in abdominal aortic aneurysm disease. Medicine and science in sports and exercise Myers, J., McElrath, M., Jaffe, A., Smith, K., Fonda, H., Vu, A., Hill, B., Dalman, R. 2014; 46 (1): 2-9


Screening programs and greater public awareness have increased the recognition of early abdominal aortic aneurysm (AAA) disease. No medical therapy has proven effective in limiting AAA progression, and little is known regarding the safety and efficacy of exercise training in these patients. We evaluated the safety and efficacy of up to 3 years of training in patients with early (=5.5 cm) AAA disease.One hundred forty patients with small AAAs (72±8 years) were randomized to exercise training (n=72) or usual care (n=68). Exercise subjects participated in a combination of in-house and home training for up to 3 years. Cardiopulmonary exercise testing (CPX) was performed at baseline and 3, 12, 24, and 36 months. Comparisons were made for AAA expansion, safety, CPX responses, and weekly energy expenditure.Average duration of participation was 23.4?±9.6 months; 81% of subjects completed = 1 year. No adverse clinical events or excessive AAA growth rates related to training occurred. Exercise subjects expended a mean 1999±1030 kcals/week. Increases in peak exercise time and estimated METs occurred at the 3 month and 1, 2, and 3-year evaluations (p<0.01 between groups). A significant between-group interaction occurred for VO2 at the ventilatory threshold (p=0.02), and submaximal heart rate was significantly reduced among exercise subjects. Neither exercise status nor level of fitness significantly influenced rate of AAA enlargement.These results support the safety and efficacy of training in patients with small AAA, a population for which few previous data are available. Despite advanced age and co-morbidities, training up to 3 years was well tolerated and sustainable in AAA patients. Training did not influence rate of AAA enlargement.

View details for DOI 10.1249/MSS.0b013e3182a088b8

View details for PubMedID 23793234