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The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade

The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade GYNECOLOGIC ONCOLOGY Kandalaft, L. E., Singh, N., Liao, J. B., Facciabene, A., Berek, J. S., Powell, D. J., Coukos, G. 2010; 116 (2): 222-233

Abstract

In the past decade we have witnessed important advances in the treatment of gynecological cancers and have recognized their potential immunogenicity. This has opened the door to explore immune therapy not only in HPV-induced cancers but also in ovarian and endometrial cancers. Here we will review the off-target immune effects of select chemotherapy drugs commonly used to treat gynecologic cancers and novel tools that can stimulate both the adaptive and innate immune mechanisms such as novel pleiotropic cytokines, Toll-like receptors, and powerful antibodies that can target inhibitory checkpoints, thereby activating effector cellular immune mechanisms and neutralizing suppressor cells. We will also review how existing drugs can be used for combinatorial tumor therapy.

View details for DOI 10.1016/j.ygyno.2009.11.001

View details for Web of Science ID 000274504200013

View details for PubMedID 19959212

View details for PubMedCentralID PMC3119495