Chronic Sacral Nerve Stimulation as a Novel Treatment for Stress Urinary Incontinence-A Rat Model

Abstract

We propose an animal model to evaluate the effect of chronic sacral nerve stimulation (SNS) on surgically induced intrinsic sphincter deficiency (ISD) secondary to transabdominal urethrolysis (U-Lys).Twenty-five 6-week old virgin female Sprague-Dawley rats were divided into four groups: control (CTRL), U-Lys only, SNS only, and both (U-Lys/SNS). Groups CTRL (N?=?5) and U-Lys only (N?=?5) were maintained in the animal research facility in standard fashion for 2 weeks. Groups SNS only (N?=?5) and U-Lys/SNS (N?=?10) underwent chronic SNS for 6 continuous hours daily for 2 weeks. Retrograde leak point pressure (RLPP) was measured at baseline and at 2 weeks following observation or treatment. Five consecutive RLPP measurements were averaged per measurement cycle. SAS 9.3 was used to evaluate means and standard deviation.Baseline mean RLPP was 65?mmHg. The U-Lys only group mean RLPP at initial urethrolysis (58?mmHg) decreased (31?mmHg, P?

View details for DOI 10.1002/nau.22550

View details for Web of Science ID 000352152900012

View details for PubMedID 24375804