THE IMMUNOLOGICAL CHARACTERIZATION OF 95 NODAL AND EXTRANODAL DIFFUSE LARGE CELL LYMPHOMAS IN 89 PATIENTS AMERICAN JOURNAL OF PATHOLOGY Doggett, R. S., Wood, G. S., Horning, S., Levy, R., Dorfman, R. F., Bindl, J., Warnke, R. A. 1984; 115 (2): 245-252

Abstract

Ninety-five diffuse large cell lymphomas in 89 patients were stained in cryostat sections with a panel of monoclonal antibodies. Lymphoma cells from 47 patients (53%) expressed either kappa or lambda light chains, usually in combination with mu heavy chains. Fifteen samples from 12 patients (14%) expressed two or more T-cell antigens and commonly expressed Ia antigens. Lymphoma cells from 10 of these patients uniformly lacked one or more pan T-cell antigens; lymphoma cells from 4 of these patients also lacked both T-subset antigens--findings which should prove useful in diagnosis. Lymphomas from 28 patients (31%) did not express immunoglobulin or T-cell antigens but commonly expressed the B-lineage antigen B1; and the remaining 9 cases generally expressed Ia antigens, common ALL antigens, or both. Our findings confirm the marked immunologic heterogeneity of diffuse large cell lymphomas; the phenotypic heterogeneity observed in T-cell cases in many instances is difficult to reconcile with current models of T-cell differentiation.

View details for Web of Science ID A1984SQ54100012

View details for PubMedID 6232854