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Association between Cellular Immune Activation, Target Cell Frequency, and Risk of Human Immunodeficiency Virus Type 1 Superinfection JOURNAL OF VIROLOGY Blish, C. A., Dogan, O. C., Jaoko, W., McClelland, R. S., Mandaliya, K., Odem-Davis, K., Richardson, B. A., Overbaugh, J. 2014; 88 (10): 5894-5899

Abstract

We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.

View details for DOI 10.1128/JVI.00187-14

View details for Web of Science ID 000335446400062

View details for PubMedID 24623424